Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of familial and sporadic Parkinson’s disease (PD). To support clinical development of LRRK2 inhibitors as disease-modifying treatment in PD biomarkers for kinase activity, target engagement and kinase inhibiti...

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Detalles Bibliográficos
Autores principales: Thirstrup, Kenneth, Dächsel, Justus C., Oppermann, Felix S., Williamson, Douglas S., Smith, Garrick P., Fog, Karina, Christensen, Kenneth V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578959/
https://www.ncbi.nlm.nih.gov/pubmed/28860483
http://dx.doi.org/10.1038/s41598-017-10501-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578959/
https://www.ncbi.nlm.nih.gov/pubmed/28860483
http://dx.doi.org/10.1038/s41598-017-10501-z

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