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Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells
Genetic variation in the leucine-rich repeat kinase 2 (LRRK2) gene is associated with risk of familial and sporadic Parkinson’s disease (PD). To support clinical development of LRRK2 inhibitors as disease-modifying treatment in PD biomarkers for kinase activity, target engagement and kinase inhibiti...
Autores principales: | Thirstrup, Kenneth, Dächsel, Justus C., Oppermann, Felix S., Williamson, Douglas S., Smith, Garrick P., Fog, Karina, Christensen, Kenneth V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578959/ https://www.ncbi.nlm.nih.gov/pubmed/28860483 http://dx.doi.org/10.1038/s41598-017-10501-z |
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