Novel quinolone chalcones targeting colchicine-binding pocket kill multidrug-resistant cancer cells by inhibiting tubulin activity and MRP1 function

Agents targeting colchicine-binding pocket usually show a minimal drug-resistance issue, albeit often associated with high toxicity. Chalcone-based compounds, which may bind to colchicine-binding site, are found in many edible fruits, suggesting that they can be effective drugs with less toxicity. T...

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Detalles Bibliográficos
Autores principales: Lindamulage, I. Kalhari, Vu, Hai-Yen, Karthikeyan, Chandrabose, Knockleby, James, Lee, Yi-Fang, Trivedi, Piyush, Lee, Hoyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578999/
https://www.ncbi.nlm.nih.gov/pubmed/28860494
http://dx.doi.org/10.1038/s41598-017-10972-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578999/
https://www.ncbi.nlm.nih.gov/pubmed/28860494
http://dx.doi.org/10.1038/s41598-017-10972-0

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