Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties

Despite the emergence of targeted therapies and immunotherapy, chemotherapy remains the gold-standard for the treatment of most patients with solid malignancies. Spindle poisons that interfere with microtubule dynamics are commonly used in chemotherapy drug combinations. However, their troublesome s...

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Detalles Bibliográficos
Autores principales: Gilson, Pauline, Josa-Prado, Fernando, Beauvineau, Claire, Naud-Martin, Delphine, Vanwonterghem, Laetitia, Mahuteau-Betzer, Florence, Moreno, Alexis, Falson, Pierre, Lafanechère, Laurence, Frachet, Véronique, Coll, Jean-Luc, Fernando Díaz, Jose, Hurbin, Amandine, Busser, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579042/
https://www.ncbi.nlm.nih.gov/pubmed/28860487
http://dx.doi.org/10.1038/s41598-017-09491-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579042/
https://www.ncbi.nlm.nih.gov/pubmed/28860487
http://dx.doi.org/10.1038/s41598-017-09491-9

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