Structural and Functional View of Polypharmacology

Protein domains mediate drug-protein interactions and this principle can guide the design of multi-target drugs i.e. polypharmacology. In this study, we associate multi-target drugs with CATH functional families through the overrepresentation of targets of those drugs in CATH functional families. Th...

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Detalles Bibliográficos
Autores principales: Moya-García, Aurelio, Adeyelu, Tolulope, Kruger, Felix A., Dawson, Natalie L., Lees, Jon G., Overington, John P., Orengo, Christine, Ranea, Juan A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579063/
https://www.ncbi.nlm.nih.gov/pubmed/28860623
http://dx.doi.org/10.1038/s41598-017-10012-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579063/
https://www.ncbi.nlm.nih.gov/pubmed/28860623
http://dx.doi.org/10.1038/s41598-017-10012-x

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