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Identification of amino acid residues involved in the dRP-lyase activity of human Pol ι

Besides X-family DNA polymerases (first of all, Pol β) several other human DNA polymerases from Y- and A- families were shown to possess the dRP-lyase activity and could serve as backup polymerases in base excision repair (Pol ι, Rev1, Pol γ and Pol θ). However the exact position of the active sites...

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Detalles Bibliográficos
Autores principales: Miropolskaya, Nataliya, Petushkov, Ivan, Kulbachinskiy, Andrey, Makarova, Alena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579206/
https://www.ncbi.nlm.nih.gov/pubmed/28860552
http://dx.doi.org/10.1038/s41598-017-10668-5