Discovery of human-like L-asparaginases with potential clinical use by directed evolution

L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar K(M) for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of ba...

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Detalles Bibliográficos
Autores principales: Rigouin, Coraline, Nguyen, Hien Anh, Schalk, Amanda M., Lavie, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579231/
https://www.ncbi.nlm.nih.gov/pubmed/28860480
http://dx.doi.org/10.1038/s41598-017-10758-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579231/
https://www.ncbi.nlm.nih.gov/pubmed/28860480
http://dx.doi.org/10.1038/s41598-017-10758-4

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