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Discovery of human-like L-asparaginases with potential clinical use by directed evolution
L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar K(M) for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of ba...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579231/ https://www.ncbi.nlm.nih.gov/pubmed/28860480 http://dx.doi.org/10.1038/s41598-017-10758-4 |