Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors

Patients with malignant peripheral nerve sheath tumor (MPNST), a rare soft tissue cancer associated with loss of the tumor suppressor neurofibromin (NF1), have poor prognosis and typically respond poorly to adjuvant therapy. We evaluated the effect of 299 clinical and investigational compounds on se...

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Detalles Bibliográficos
Autores principales: Kolberg, Matthias, Bruun, Jarle, Murumägi, Astrid, Mpindi, John P., Bergsland, Christian H., Høland, Maren, Eilertsen, Ina A., Danielsen, Stine A., Kallioniemi, Olli, Lothe, Ragnhild A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579334/
https://www.ncbi.nlm.nih.gov/pubmed/28556483
http://dx.doi.org/10.1002/1878-0261.12086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579334/
https://www.ncbi.nlm.nih.gov/pubmed/28556483
http://dx.doi.org/10.1002/1878-0261.12086

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