Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling

In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased th...

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Detalles Bibliográficos
Autores principales: Kim, Ji Cheol, Jung, Young Su, Lee, Ha Young, Park, Joon Seong, Bae, Yoe-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579511/
https://www.ncbi.nlm.nih.gov/pubmed/28857084
http://dx.doi.org/10.1038/emm.2017.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579511/
https://www.ncbi.nlm.nih.gov/pubmed/28857084
http://dx.doi.org/10.1038/emm.2017.120

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