Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

[Image: see text] Pyruvate formate-lyase activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically essential glycyl radical on pyruvate formate-lyase. We show that PFL-AE binds a catalytically essential monovalent cation at its active site, yet anothe...

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Detalles Bibliográficos
Autores principales: Shisler, Krista A., Hutcheson, Rachel U., Horitani, Masaki, Duschene, Kaitlin S., Crain, Adam V., Byer, Amanda S., Shepard, Eric M., Rasmussen, Ashley, Yang, Jian, Broderick, William E., Vey, Jessica L., Drennan, Catherine L., Hoffman, Brian M., Broderick, Joan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579537/
https://www.ncbi.nlm.nih.gov/pubmed/28768413
http://dx.doi.org/10.1021/jacs.7b04883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579537/
https://www.ncbi.nlm.nih.gov/pubmed/28768413
http://dx.doi.org/10.1021/jacs.7b04883

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