Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine

A highly integrated approach to the development of a process for the continuous synthesis and purification of diphenhydramine is reported. Mass spectrometry (MS) is utilized throughout the system for on-line reaction monitoring, off-line yield quantitation, and as a reaction screening module that ex...

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Detalles Bibliográficos
Autores principales: Loren, Bradley P., Wleklinski, Michael, Koswara, Andy, Yammine, Kathryn, Hu, Yanyang, Nagy, Zoltan K., Thompson, David H., Cooks, R. Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580336/
https://www.ncbi.nlm.nih.gov/pubmed/28979759
http://dx.doi.org/10.1039/c7sc00905d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580336/
https://www.ncbi.nlm.nih.gov/pubmed/28979759
http://dx.doi.org/10.1039/c7sc00905d

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