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Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine
A highly integrated approach to the development of a process for the continuous synthesis and purification of diphenhydramine is reported. Mass spectrometry (MS) is utilized throughout the system for on-line reaction monitoring, off-line yield quantitation, and as a reaction screening module that ex...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580336/ https://www.ncbi.nlm.nih.gov/pubmed/28979759 http://dx.doi.org/10.1039/c7sc00905d |