SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

R loops are three-stranded nucleic acid structures consisting of an RNA:DNA heteroduplex and a “looped-out” nontemplate strand. As aberrant formation and persistence of R loops block transcription elongation and cause DNA damage, mechanisms that resolve R loops are essential for genome stability. He...

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Detalles Bibliográficos
Autores principales: Song, Chenlin, Hotz-Wagenblatt, Agnes, Voit, Renate, Grummt, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580657/
https://www.ncbi.nlm.nih.gov/pubmed/28790157
http://dx.doi.org/10.1101/gad.300624.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580657/
https://www.ncbi.nlm.nih.gov/pubmed/28790157
http://dx.doi.org/10.1101/gad.300624.117

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