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Mechanistic basis for the recognition of laminin-511 by α6β1 integrin

Laminins regulate diverse cellular functions through interaction with integrins. Two regions of laminins—three laminin globular domains of the α chain (LG1–3) and the carboxyl-terminal tail of the γ chain (γ-tail)—are required for integrin binding, but it remains unclear how the γ-tail contributes t...

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Detalles Bibliográficos
Autores principales: Takizawa, Mamoru, Arimori, Takao, Taniguchi, Yukimasa, Kitago, Yu, Yamashita, Erika, Takagi, Junichi, Sekiguchi, Kiyotoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580876/
https://www.ncbi.nlm.nih.gov/pubmed/28879238
http://dx.doi.org/10.1126/sciadv.1701497