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Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in bot...

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Detalles Bibliográficos
Autores principales: Brandt, Tobias, Mourier, Arnaud, Tain, Luke S, Partridge, Linda, Larsson, Nils-Göran, Kühlbrandt, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580880/
https://www.ncbi.nlm.nih.gov/pubmed/28699890
http://dx.doi.org/10.7554/eLife.24662