Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement

Cancers employ a number of mechanisms to evade host immune responses. Here we report the effects of tumor-shed antigen CA125/MUC16 on suppressing IgG1-mediated antibody-dependent cellular cytotoxicity (ADCC). This evidence stems from prespecified subgroup analysis of a Phase 3 clinical trial testing...

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Detalles Bibliográficos
Autores principales: Kline, James Bradford, Kennedy, Rina P., Albone, Earl, Chao, Qimin, Fernando, Shawn, McDonough, Jennifer M., Rybinski, Katherine, Wang, Wenquan, Somers, Elizabeth B., Schweizer, Charles, Grasso, Luigi, Nicolaides, Nicholas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581011/
https://www.ncbi.nlm.nih.gov/pubmed/28881712
http://dx.doi.org/10.18632/oncotarget.19090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581011/
https://www.ncbi.nlm.nih.gov/pubmed/28881712
http://dx.doi.org/10.18632/oncotarget.19090

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