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Tumor antigen CA125 suppresses antibody-dependent cellular cytotoxicity (ADCC) via direct antibody binding and suppressed Fc-γ receptor engagement

Cancers employ a number of mechanisms to evade host immune responses. Here we report the effects of tumor-shed antigen CA125/MUC16 on suppressing IgG1-mediated antibody-dependent cellular cytotoxicity (ADCC). This evidence stems from prespecified subgroup analysis of a Phase 3 clinical trial testing...

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Detalles Bibliográficos
Autores principales:	Kline, James Bradford, Kennedy, Rina P., Albone, Earl, Chao, Qimin, Fernando, Shawn, McDonough, Jennifer M., Rybinski, Katherine, Wang, Wenquan, Somers, Elizabeth B., Schweizer, Charles, Grasso, Luigi, Nicolaides, Nicholas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581011/ https://www.ncbi.nlm.nih.gov/pubmed/28881712 http://dx.doi.org/10.18632/oncotarget.19090

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