siRNA-mediated inactivation of HER3 improves the antitumour activity and sensitivity of gefitinib in gastric cancer cells

The human EGFR family consists of four type-1 transmembrane tyrosine kinase receptors: HER1 (EGFR, ErbB1), HER2 (Neu, ErbB2), HER3 (ErbB3), and HER4 (ErbB4). HER3 can dimerize with EGFR, HER2 and even c-Met and likely plays a central role in the response to EGFR-targeted therapy. Because HER3 lacks...

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Detalles Bibliográficos
Autores principales: Yuan, Heng-Heng, Yang, Ying-Nan, Zhou, Jian-Hua, Li, Yan-Jing, Wang, Li-Ying, Qin, Jun-Wei, Liu, Tao, Li, Zhen-Zhen, Zhou, Qing-Xin, Wei, Xiao-Li, Zhang, Ting-Ting, Huang, Peng, Zhang, Wen-Jie, Liu, Lei, Du, Xiao-Xue, Han, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581052/
https://www.ncbi.nlm.nih.gov/pubmed/28881753
http://dx.doi.org/10.18632/oncotarget.17526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581052/
https://www.ncbi.nlm.nih.gov/pubmed/28881753
http://dx.doi.org/10.18632/oncotarget.17526

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