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MM-BMSCs induce naïve CD4+ T lymphocytes dysfunction through fibroblast activation protein α

BACKGROUND: The tumor microenvironment plays a major role in multiple myelomas (MM). MM-BMSCs (bone marrow mesenchymal stromal cells) can support tumor growth and immune surveillance escape. On the other hand, fibroblast activation protein α, expressed by cancer stroma cells including BMSCs, has bee...

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Detalles Bibliográficos
Autores principales: Wu, Xiaofei, Wang, Yadan, Xu, Jian, Luo, Ting, Deng, Jun, Hu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581055/
https://www.ncbi.nlm.nih.gov/pubmed/28881756
http://dx.doi.org/10.18632/oncotarget.17538