Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury

OBJECTIVE: To explore the effects of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain (CNP) and spinal microglia in a rat model of chronic constriction injury (CCI). METHODS: Male SD rats were assigned into control, sham, CCI, wortmannin, dimethyl sulfoxide (DMSO) and wortmanni...

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Detalles Bibliográficos
Autores principales: Guo, Jian-Rong, Wang, Huan, Jin, Xiao-Ju, Jia, Dong-Lin, Zhou, Xun, Tao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581082/
https://www.ncbi.nlm.nih.gov/pubmed/28881783
http://dx.doi.org/10.18632/oncotarget.17629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581082/
https://www.ncbi.nlm.nih.gov/pubmed/28881783
http://dx.doi.org/10.18632/oncotarget.17629

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