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Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp(3) Centers Enhance Target Selectivity
Dark chemical matter compounds are small molecules that have been recently identified as highly potent and selective hits. For this reason, they constitute a promising class of possible candidates in the process of drug discovery and raise the interest of the scientific community. To this purpose, W...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581349/ https://www.ncbi.nlm.nih.gov/pubmed/28894419 http://dx.doi.org/10.3389/fphar.2017.00552 |