Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Clinical application of lentiviral vector (LV)‐based hematopoietic stem and progenitor cells (HSPC) gene therapy is rapidly becoming a reality. Nevertheless, LV‐mediated signaling and its potential functional consequences on HSPC biology remain poorly understood. We unravel here a remarkably limited...

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Detalles Bibliográficos
Autores principales: Piras, Francesco, Riba, Michela, Petrillo, Carolina, Lazarevic, Dejan, Cuccovillo, Ivan, Bartolaccini, Sara, Stupka, Elia, Gentner, Bernhard, Cittaro, Davide, Naldini, Luigi, Kajaste‐Rudnitski, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582409/
https://www.ncbi.nlm.nih.gov/pubmed/28667090
http://dx.doi.org/10.15252/emmm.201707922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582409/
https://www.ncbi.nlm.nih.gov/pubmed/28667090
http://dx.doi.org/10.15252/emmm.201707922

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