MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

Hutchinson–Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A‐type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing, accumulates in HGPS cells' nuclei and is a hallmark of the...

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Detalles Bibliográficos
Autores principales: Harhouri, Karim, Navarro, Claire, Depetris, Danielle, Mattei, Marie‐Geneviève, Nissan, Xavier, Cau, Pierre, De Sandre‐Giovannoli, Annachiara, Lévy, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582415/
https://www.ncbi.nlm.nih.gov/pubmed/28674081
http://dx.doi.org/10.15252/emmm.201607315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582415/
https://www.ncbi.nlm.nih.gov/pubmed/28674081
http://dx.doi.org/10.15252/emmm.201607315

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