Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina

Plants create tremendous chemical diversity from a single biosynthetic intermediate. In plant‐derived ajmalan alkaloid pathways, the biosynthetic intermediate vomilenine can be transformed into the anti‐arrhythmic compound ajmaline, or alternatively, can isomerize to form perakine, an alkaloid with...

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Detalles Bibliográficos
Autores principales: Dang, Thu‐Thuy T., Franke, Jakob, Tatsis, Evangelos, O'Connor, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582599/
https://www.ncbi.nlm.nih.gov/pubmed/28654178
http://dx.doi.org/10.1002/anie.201705010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582599/
https://www.ncbi.nlm.nih.gov/pubmed/28654178
http://dx.doi.org/10.1002/anie.201705010

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