A modeling approach to evaluate the balance between bioactivation and detoxification of MeIQx in human hepatocytes

BACKGROUND: Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are potentially carcinogenic for humans. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is one of the most abundant HAA formed in cooked meat. MeIQx is metabolized by cytochrome P450 1A2 in the human l...

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Detalles Bibliográficos
Autores principales: Delannée, Victorien, Langouët, Sophie, Théret, Nathalie, Siegel, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582613/
https://www.ncbi.nlm.nih.gov/pubmed/28879062
http://dx.doi.org/10.7717/peerj.3703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582613/
https://www.ncbi.nlm.nih.gov/pubmed/28879062
http://dx.doi.org/10.7717/peerj.3703

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