Intrathecal administration of AYX2 DNA decoy produces a long-term pain treatment in rat models of chronic pain by inhibiting the KLF6, KLF9, and KLF15 transcription factors

BACKGROUND: Nociception is maintained by genome-wide regulation of transcription in the dorsal root ganglia—spinal cord network. Hence, transcription factors constitute a promising class of targets for breakthrough pharmacological interventions to treat chronic pain. DNA decoys are oligonucleotides...

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Detalles Bibliográficos
Autores principales: Mamet, Julien, Klukinov, Michael, Harris, Scott, Manning, Donald C, Xie, Simon, Pascual, Conrado, Taylor, Bradley K, Donahue, Renee R, Yeomans, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582654/
https://www.ncbi.nlm.nih.gov/pubmed/28814144
http://dx.doi.org/10.1177/1744806917727917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582654/
https://www.ncbi.nlm.nih.gov/pubmed/28814144
http://dx.doi.org/10.1177/1744806917727917

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