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MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1
Murine double minute 2 (MDM2) is an E3-ubiquitin ligase critical for various biological functions. Previous data have revealed an indispensable role of MDM2 in kidney homeostasis. However, its role in glomerular mesangial cell (GMC) proliferation and extracellular matrix (ECM) accumulation during hy...
Autores principales: | Lei, Chun-Tao, Tang, Hui, Ye, Chen, You, Chao-Qun, Zhang, Jiao, Zhang, Chun-Yun, Xiong, Wei, Su, Hua, Zhang, Chun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583188/ https://www.ncbi.nlm.nih.gov/pubmed/28871126 http://dx.doi.org/10.1038/s41598-017-10927-5 |
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