Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy

Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which drives mitochondria into autophagy without collaps...

Descripción completa

Detalles Bibliográficos
Autores principales: Georgakopoulos, Nikolaos D., Frison, Michele, Alvarez, Maria Soledad, Bertrand, Hélène, Wells, Geoff, Campanella, Michelangelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583253/
https://www.ncbi.nlm.nih.gov/pubmed/28871145
http://dx.doi.org/10.1038/s41598-017-07679-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583253/
https://www.ncbi.nlm.nih.gov/pubmed/28871145
http://dx.doi.org/10.1038/s41598-017-07679-7

Ejemplares similares