Rapid LC-MS Based High-Throughput Screening Method, Affording No False Positives or False Negatives, Identifies a New Inhibitor for Carbonic Anhydrase

Developing effective high-throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. While rugged and robust assays may be easily developed for certain enzymes, HTS assays designed to identify ligands that block protein binding are much more challenging to de...

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Detalles Bibliográficos
Autores principales: Imaduwage, Kasun P., Lakbub, Jude, Go, Eden P., Desaire, Heather
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583356/
https://www.ncbi.nlm.nih.gov/pubmed/28871149
http://dx.doi.org/10.1038/s41598-017-08602-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583356/
https://www.ncbi.nlm.nih.gov/pubmed/28871149
http://dx.doi.org/10.1038/s41598-017-08602-w

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