Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery

Pigment epithelium derived factor (PEDF) is a potent antiangiogenic, neurotrophic, and neuroprotective molecule that is the endogenous inhibitor of vascular endothelial growth factor (VEGF) in the retina. An ex vivo gene therapy approach based on transgenic overexpression of PEDF in the eye is assum...

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Detalles Bibliográficos
Autores principales: Garcia-Garcia, Laura, Recalde, Sergio, Hernandez, Maria, Bezunartea, Jaione, Rodriguez-Madoz, Juan Roberto, Johnen, Sandra, Diarra, Sabine, Marie, Corinne, Izsvák, Zsuzsanna, Ivics, Zoltán, Scherman, Daniel, Kropp, Martina, Thumann, Gabriele, Prosper, Felipe, Fernandez-Robredo, Patricia, Garcia-Layana, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583395/
https://www.ncbi.nlm.nih.gov/pubmed/29246287
http://dx.doi.org/10.1016/j.omtn.2017.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583395/
https://www.ncbi.nlm.nih.gov/pubmed/29246287
http://dx.doi.org/10.1016/j.omtn.2017.08.001

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