An essential role of high-molecular-weight kininogen in endotoxemia

In this study, we show that mice lacking high-molecular-weight kininogen (HK) were resistant to lipopolysaccharide (LPS)-induced mortality and had significantly reduced circulating LPS levels. Replenishment of HK-deficient mice with human HK recovered the LPS levels and rendered the mice susceptible...

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Detalles Bibliográficos
Autores principales: Yang, Aizhen, Xie, Zhanli, Wang, Bo, Colman, Robert W., Dai, Jihong, Wu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584120/
https://www.ncbi.nlm.nih.gov/pubmed/28794132
http://dx.doi.org/10.1084/jem.20161900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584120/
https://www.ncbi.nlm.nih.gov/pubmed/28794132
http://dx.doi.org/10.1084/jem.20161900

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