Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling

Autosomal-recessive omodysplasia (OMOD1) is a genetic condition characterized by short stature, shortened limbs, and facial dysmorphism. OMOD1 is caused by loss-of-function mutations of glypican 6 (GPC6). In this study, we show that GPC6-null embryos display most of the abnormalities found in OMOD1...

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Detalles Bibliográficos
Autores principales: Capurro, Mariana, Izumikawa, Tomomi, Suarez, Philippe, Shi, Wen, Cydzik, Marzena, Kaneiwa, Tomoyuki, Gariepy, Jean, Bonafe, Luisa, Filmus, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584141/
https://www.ncbi.nlm.nih.gov/pubmed/28696225
http://dx.doi.org/10.1083/jcb.201605119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584141/
https://www.ncbi.nlm.nih.gov/pubmed/28696225
http://dx.doi.org/10.1083/jcb.201605119

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