Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis

In sporadic colon cancer, colon cancer stem cells (CCSCs) initiate tumorigenesis and may contribute to late disease recurrences and metastases. We previously showed that aldehyde dehydrogenase (ALDH) activity (as indicated by the ALDEFLUOR(®) assay) is an effective marker for highly enriching CCSCs...

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Detalles Bibliográficos
Autores principales: Chen, Sugong, Fisher, Robert C., Signs, Steven, Molina, L. Alex, Shenoy, Anitha K., Lopez, Maria-Cecilia, Baker, Henry V., Koomen, John M., Chen, Yi, Gittleman, Haley, Barnholtz-Sloan, Jill, Berg, Annamarie, Appelman, Henry D., Huang, Emina H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584153/
https://www.ncbi.nlm.nih.gov/pubmed/28881576
http://dx.doi.org/10.18632/oncotarget.9919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584153/
https://www.ncbi.nlm.nih.gov/pubmed/28881576
http://dx.doi.org/10.18632/oncotarget.9919

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