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Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1
The HECT-type ubiquitin ligase Smurf1 (Smad ubiquitination regulatory factor-1) plays the prominent role in regulation of bone formation, embryonic development, and tumorigenesis by directing the ubiquitin-proteasomal degradation of specific targets. In contrast with RING-type E3s, the catalytic HEC...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584161/ https://www.ncbi.nlm.nih.gov/pubmed/28881580 http://dx.doi.org/10.18632/oncotarget.10648 |