Decreased calpain activity in chronic myeloid leukemia impairs apoptosis by increasing survivin in myeloid progenitors and xiap1 in differentiating granulocytes

Chronic Myeloid Leukemia (CML) is characterized by translocations between chromosomes 9 and 22, resulting in expression of Bcr-abl oncogenes. Although the clinical course of CML was revolutionized by development of Bcr-abl-directed tyrosine kinase inhibitors (TKIs), CML is not cured by these agents....

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Detalles Bibliográficos
Autores principales: Huang, Weiqi, Bei, Ling, Hjort, Elizabeth E., Eklund, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584179/
https://www.ncbi.nlm.nih.gov/pubmed/28881589
http://dx.doi.org/10.18632/oncotarget.16884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584179/
https://www.ncbi.nlm.nih.gov/pubmed/28881589
http://dx.doi.org/10.18632/oncotarget.16884

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