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Decreased calpain activity in chronic myeloid leukemia impairs apoptosis by increasing survivin in myeloid progenitors and xiap1 in differentiating granulocytes

Chronic Myeloid Leukemia (CML) is characterized by translocations between chromosomes 9 and 22, resulting in expression of Bcr-abl oncogenes. Although the clinical course of CML was revolutionized by development of Bcr-abl-directed tyrosine kinase inhibitors (TKIs), CML is not cured by these agents....

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Detalles Bibliográficos
Autores principales:	Huang, Weiqi, Bei, Ling, Hjort, Elizabeth E., Eklund, Elizabeth A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584179/ https://www.ncbi.nlm.nih.gov/pubmed/28881589 http://dx.doi.org/10.18632/oncotarget.16884

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