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Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584192/ https://www.ncbi.nlm.nih.gov/pubmed/28811278 http://dx.doi.org/10.1083/jcb.201707090 |