Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis

The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repr...

Descripción completa

Detalles Bibliográficos
Autores principales: Elzeneini, Eman, Wickström, Sara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584192/
https://www.ncbi.nlm.nih.gov/pubmed/28811278
http://dx.doi.org/10.1083/jcb.201707090
_version_ 1783261427372392448
author Elzeneini, Eman
Wickström, Sara A.
author_facet Elzeneini, Eman
Wickström, Sara A.
author_sort Elzeneini, Eman
collection PubMed
description The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease.
format Online
Article
Text
id pubmed-5584192
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-55841922018-03-04 Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis Elzeneini, Eman Wickström, Sara A. J Cell Biol Commentary The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease. The Rockefeller University Press 2017-09-04 /pmc/articles/PMC5584192/ /pubmed/28811278 http://dx.doi.org/10.1083/jcb.201707090 Text en © 2017 Elzeneini and Wickström http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Elzeneini, Eman
Wickström, Sara A.
Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
title Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
title_full Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
title_fullStr Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
title_full_unstemmed Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
title_short Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis
title_sort lipodystrophic laminopathy: lamin a mutation relaxes chromatin architecture to impair adipogenesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584192/
https://www.ncbi.nlm.nih.gov/pubmed/28811278
http://dx.doi.org/10.1083/jcb.201707090
work_keys_str_mv AT elzeneinieman lipodystrophiclaminopathylaminamutationrelaxeschromatinarchitecturetoimpairadipogenesis
AT wickstromsaraa lipodystrophiclaminopathylaminamutationrelaxeschromatinarchitecturetoimpairadipogenesis

Ejemplares similares