GSK1059615 kills head and neck squamous cell carcinoma cells possibly via activating mitochondrial programmed necrosis pathway

This study tested the anti-head and neck squamous cell carcinoma (HNSCC) cell activity by GSK1059615, a novel PI3K and mTOR dual inhibitor. GSK1059615 inhibited survival and proliferation of established (SCC-9, SQ20B and A253 lines) and primary human HNSCC cells. GSK1059615 blocked PI3K-AKT-mTOR act...

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Detalles Bibliográficos
Autores principales: Xie, Jing, Li, Quan, Ding, Xi, Gao, Yunyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584207/
https://www.ncbi.nlm.nih.gov/pubmed/28881606
http://dx.doi.org/10.18632/oncotarget.15135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584207/
https://www.ncbi.nlm.nih.gov/pubmed/28881606
http://dx.doi.org/10.18632/oncotarget.15135

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