BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1)

Ovarian cancer (OC) is a heterogeneous disease characterized by defective DNA repair. Very few targets are universally expressed in the high grade serous (HGS) subtype. We previously identified that CHK1 was overexpressed in most of HGSOC. Here, we sought to understand the DNA damage response (DDR)...

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Detalles Bibliográficos
Autores principales: Pongas, Georgios, Kim, Marianne K., Min, Dong J., House, Carrie D., Jordan, Elizabeth, Caplen, Natasha, Chakka, Sirisha, Ohiri, Joyce, Kruhlak, Michael J., Annunziata, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584257/
https://www.ncbi.nlm.nih.gov/pubmed/28881656
http://dx.doi.org/10.18632/oncotarget.17572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584257/
https://www.ncbi.nlm.nih.gov/pubmed/28881656
http://dx.doi.org/10.18632/oncotarget.17572

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