Cargando…

Autophagy is required for crizotinib-induced apoptosis in MET-amplified gastric cancer cells

MET amplification has been clinically credentialed as a therapeutic target in gastric cancer, but the molecular mechanisms underlying sensitivity and resistance to MET inhibitors are still not well understood. Using whole-genome mRNA expression profiling, we identified autophagy as a top molecular p...

Descripción completa

Detalles Bibliográficos
Autores principales: Schroeder, Rebecca D., Choi, Woonyoung, Hong, David S., McConkey, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584279/
https://www.ncbi.nlm.nih.gov/pubmed/28881678
http://dx.doi.org/10.18632/oncotarget.18386