Inhibition of FAK kinase activity preferentially targets cancer stem cells

Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical challenges to cancer treatment. VS-4718 and VS-6063 are potent inhibitors of focal adhesion kinase (FAK), a non-receptor t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolev, Vihren N., Tam, Winnie F., Wright, Quentin G., McDermott, Sean P., Vidal, Christian M., Shapiro, Irina M., Xu, Qunli, Wicha, Max S., Pachter, Jonathan A., Weaver, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584283/
https://www.ncbi.nlm.nih.gov/pubmed/28881682
http://dx.doi.org/10.18632/oncotarget.18517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584283/
https://www.ncbi.nlm.nih.gov/pubmed/28881682
http://dx.doi.org/10.18632/oncotarget.18517

Ejemplares similares