Comprehensive analyses of somatic TP53 mutation in tumors with variable mutant allele frequency

Somatic mutation of the tumor suppressor gene TP53 is reported in at least 50% of human malignancies. Most high-grade serous ovarian cancers (HGSC) have a mutant TP53 allele. Accurate detection of these mutants in heterogeneous tumor tissue is paramount as therapies emerge to target mutant p53. We u...

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Detalles Bibliográficos
Autores principales: Cole, Alexander J., Zhu, Ying, Dwight, Trisha, Yu, Bing, Dickson, Kristie-Ann, Gard, Gregory B., Maidens, Jayne, Valmadre, Susan, Gill, Anthony J., Clifton-Bligh, Roderick, Marsh, Deborah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584393/
https://www.ncbi.nlm.nih.gov/pubmed/28872635
http://dx.doi.org/10.1038/sdata.2017.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584393/
https://www.ncbi.nlm.nih.gov/pubmed/28872635
http://dx.doi.org/10.1038/sdata.2017.120

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