The role of MAP2 kinases and p38 kinase in acute murine liver injury models

c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release. ROS produc...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Jun, Min, Robert W M, Le, Khanh, Zhou, Sheng, Aghajan, Mariam, Than, Tin A, Win, Sanda, Kaplowitz, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584575/
https://www.ncbi.nlm.nih.gov/pubmed/28661486
http://dx.doi.org/10.1038/cddis.2017.295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584575/
https://www.ncbi.nlm.nih.gov/pubmed/28661486
http://dx.doi.org/10.1038/cddis.2017.295

Ejemplares similares