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The role of MAP2 kinases and p38 kinase in acute murine liver injury models

c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release. ROS produc...

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Detalles Bibliográficos
Autores principales:	Zhang, Jun, Min, Robert W M, Le, Khanh, Zhou, Sheng, Aghajan, Mariam, Than, Tin A, Win, Sanda, Kaplowitz, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584575/ https://www.ncbi.nlm.nih.gov/pubmed/28661486 http://dx.doi.org/10.1038/cddis.2017.295

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