Phosphorylation of p53 at threonine 155 is required for Jab1-mediated nuclear export of p53

The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood. Here, we show that phosphorylation at the threonine 155 residue is essential for Jab1-mediated p53 nuclear export. Jab1 stimulated phosphoryla...

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Detalles Bibliográficos
Autores principales: Lee, Eun-Woo, Oh, Wonkyung, Song, Hosung Paul, Kim, Won Kon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584745/
https://www.ncbi.nlm.nih.gov/pubmed/28539160
http://dx.doi.org/10.5483/BMBRep.2017.50.7.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584745/
https://www.ncbi.nlm.nih.gov/pubmed/28539160
http://dx.doi.org/10.5483/BMBRep.2017.50.7.077

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