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Identifying genetic variants that affect viability in large cohorts

A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness. As a step towards this goal, we developed a method to examine whether individual genetic variants, or sets of genetic variants, currently influence viability. Th...

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Detalles Bibliográficos
Autores principales: Mostafavi, Hakhamanesh, Berisa, Tomaz, Day, Felix R., Perry, John R. B., Przeworski, Molly, Pickrell, Joseph K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584811/
https://www.ncbi.nlm.nih.gov/pubmed/28873088
http://dx.doi.org/10.1371/journal.pbio.2002458