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Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis

BACKGROUND: Progressive fibrous thickening of the peritoneal membrane is a complication of long-term peritoneal dialysis (PD). TGF-β/Smad pathway activation, inflammation, and neoangiogenesis play important roles in peritoneal membrane (PM) changes induced by PD. Recently, histone deacetilase inhibi...

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Detalles Bibliográficos
Autores principales: Costalonga, Elerson C., de Freitas, Luiza J., Aragone, Deise da S. P., Silva, Filipe M. O., Noronha, Irene L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584960/
https://www.ncbi.nlm.nih.gov/pubmed/28873458
http://dx.doi.org/10.1371/journal.pone.0184302