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Selection for energy efficiency drives strand-biased gene distribution in prokaryotes
Lagging-strand genes accumulate more deleterious mutations. Genes are thus preferably located on the leading strand, an observation known as strand-biased gene distribution (SGD). Despite of this mechanistic understanding, a satisfactory quantitative model is still lacking. Replication-transcription...
Autores principales: | Gao, Na, Lu, Guanting, Lercher, Martin J., Chen, Wei-Hua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585166/ https://www.ncbi.nlm.nih.gov/pubmed/28874819 http://dx.doi.org/10.1038/s41598-017-11159-3 |
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